Matching meals to metabolism
Genes, microbes and other factors govern how each person’s
body processes nutrients. Understanding the connections could help
optimize diets — and health.
....MUCH MOREFor many years, researchers and clinicians assumed that nutrition was a one-size-fits-all affair. Everybody needs the same nutrients from their food, they thought, and a vitamin pill or two could help dispense with any deficiencies.But now scientists are learning that our genes and environment, along with the microbes that dwell in us and other factors, alter our individual abilities to make and process nutrients. These differences mean that two given people can respond to identical diets in different ways, contributing to varied health outcomes and patterns of disease.
Until recently, scientists didn’t fully appreciate that individual metabolic differences can have a big impact on how diet affects the risk for chronic diseases, says Steven Zeisel, director of the Nutrition Research Institute at the University of North Carolina, Chapel Hill. The new knowledge is resolving long-standing mysteries about human health and paving the way toward a world of “precision nutrition,” Zeisel writes in a recent article in the Annual Review of Food Science and Technology.
Although the findings are unlikely to lead all the way to hyper-individualized dietary recommendations, they could help to tailor nutrition to subsets of people depending on their genetics or other factors: Zeisel’s company, SNP Therapeutics, is working on a test for the genetic patterns of 20-odd variants that can identify individuals at risk of fatty liver disease, for example. Knowable Magazine spoke with Zeisel about our developing understanding of precision nutrition.
This interview has been edited for length and clarity.
Why has nutrition lagged behind other research areas in medicine?
Nutrition studies have always had a problem with variability in experimental results. For instance, when infants were given the fatty acid DHA [docosahexaenoic acid], some had an improvement in their cognitive performance and others didn’t. Because some showed improvements, it was added to infant formula. But we didn’t understand why they were responding differently, so scientists continued to debate why we did this if only 15 percent of children improved and 85 percent showed no response.
The confusion came from an expectation that everybody was essentially the same. People didn’t realize that there were predictable sources of variation that could separate those who responded to something from those who did not. For DHA, it turned out that if the mother had a difference in her genes that made her slow to produce DHA, then her baby needed extra DHA and responded when given it. That gene difference occurs in about 15 percent of women — and, it turns out, it’s their babies that get better when given DHA....
DHA, EPA: very important for moms and kids.
And the paper:
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity
....MUCH MOREAnnual Review of Food Science and TechnologyVol. 11:71-92 (Volume publication date March 2020)
First published as a Review in Advance on January 13, 2020
https://doi.org/10.1146/annurev-food-032519-051736
