Ray Kurzweil at Wired, June 13:
In The Singularity Is Nearer: When We Merge With AI, the spiritual sequel to his (in)famous 2005 book, Ray Kurzweil doubles down on the promise of immortality.
We are now in the later stages
of the first generation of life extension, which involves applying the
current class of pharmaceutical and nutritional knowledge to overcoming
health challenges. In the 2020s we are starting the second phase of life
extension, which is the merger of biotechnology with AI. The 2030s will
usher in the third phase of life extension, which will be to use
nanotechnology to overcome the limitations of our biological organs
altogether. As we enter this phase, we’ll greatly extend our lives,
allowing people to far transcend the normal human limit of 120 years.
Only
one person, Jeanne Calment—a French woman who survived to age 122—is
documented to have lived longer than 120 years. So why is this such a
hard limit to human longevity? One might guess that the reasons people
don’t make it past this age are statistical—that elderly people face a
certain risk of Alzheimer’s, stroke, heart attack, or cancer every year,
and that after enough years being exposed to these risks, everyone
eventually dies of something. But that’s not what’s happening. Actuarial
data shows that from age 90 to 110, a person’s chances of dying in the
following year increase by about 2 percentage points annually. For
example, an American man at age 97 has about a 30 percent chance of
dying before 98, and if he makes it that far he will have a 32 percent
chance of dying before 99. But from age 110 onward, the risk of death
rises by about 3.5 percentage points a year.
Doctors
have offered an explanation: At around age 110, the bodies of the
oldest people start breaking down in ways that are qualitatively
different from the aging of younger senior citizens. Supercentenarian
(110-plus) aging is not simply a continuation or worsening of the same
kinds of statistical risks of late adulthood. While people at that age
also have an annual risk from ordinary diseases (although the worsening
of these risks may decelerate in the very old), they additionally face
new challenges like kidney failure and respiratory failure. These often
seem to happen spontaneously—not as a result of lifestyle factors or any
disease onset. The body apparently just starts breaking down.
Over
the past decade, scientists and investors have started giving much more
serious attention to finding out why. One of the leading researchers in
this field is biogerontologist Aubrey de Grey, founder of the LEV
(Longevity Escape Velocity) foundation. As de Grey explains, aging is
like the wear on the engine of an automobile—it is damage that
accumulates as a result of the system’s normal operation. In the human
body’s case, that damage largely comes from a combination of cellular
metabolism and cellular reproduction. Metabolism creates waste in and
around cells and damages structures through oxidation (much like the
rusting of a car!). When we’re young, our bodies are able to remove this
waste and repair the damage efficiently. But as we get older, most of
our cells reproduce over and over, and errors accumulate. Eventually the
damage starts piling up faster than the body can fix it.
The
only solution, longevity researchers argue, is to cure aging itself. In
short, we need the ability to repair damage from aging at the level of
individual cells and local tissues. There are a number of possibilities
being explored for how to achieve this, but I believe the most promising
ultimate solution is nanorobots.
And
we don’t need to wait until these technologies are fully mature in
order to benefit. If you can live long enough for anti-aging research to
start adding at least one year to your remaining life expectancy
annually, that will buy enough time for nanomedicine to cure any
remaining facets of aging. This is longevity escape velocity. This is
why there is sound logic behind Aubrey de Grey’s sensational declaration
that the first person to live to 1,000 years has likely already been
born. If the nanotechnology of 2050 solves enough issues of aging for
100-year-olds to start living to 150, we’ll then have until 2100 to
solve whatever new problems may crop up at that age. With AI playing a
key role in research by then, progress during that time will be
exponential. So even though these projections are admittedly
startling—and even sound absurd to our intuitive for linear thinking—we
have solid reasons to see this as a likely future.
I’ve had many
conversations over the years about life extension, and the idea often
meets resistance. People become upset when they hear of an individual
whose life has been cut short by a disease, yet when confronted with the
possibility of generally extending all human life, they react
negatively. “Life is too difficult to contemplate going on indefinitely”
is a common response. But people generally do not want to end their
lives at any point unless they are in enormous pain—physically,
mentally, or spiritually. And if they were to absorb the ongoing
improvements of life in all its dimensions, most such afflictions would
be alleviated. That is, extending human life would also mean vastly
improving it.
But how will nanotechnology actually
make this possible? In my view, the long-term goal is medical
nanorobots. These will be made from diamondoid parts with onboard
sensors, manipulators, computers, communicators, and possibly power
supplies. It is intuitive to imagine nanobots as tiny metal robotic
submarines chugging through the bloodstream, but physics at the
nanoscale requires a substantially different approach. At this scale,
water is a powerful solvent, and oxidant molecules are highly reactive,
so strong materials like diamondoid will be needed.
And
whereas macro-scale submarines can smoothly propel themselves through
liquids, for nanoscale objects, fluid dynamics are dominated by sticky
frictional forces. Imagine trying to swim through peanut butter! So
nanobots will need to harness different principles of propulsion.
Likewise, nanobots probably won’t be able to store enough onboard energy
or computing power to accomplish all their tasks independently, so they
will need to be designed to draw energy from their surroundings and
either obey outside control signals or collaborate with one another to
do computation....
....MUCH MORE
Fluid dynamics, very important. Provide a proof of the "Navier–Stokes Equation" and win yourself a million bucks. And that's just the start of the opportunity. It might be as large as a trillion dollars.
If interested see:
January 2020 The Trouble With Turbulence In the introduction to a post on fish and the Little Ice Age last July I mentioned how mind-bendingly complex fluid dynamics can be.September 2021
Fluid Dynamics (and the filth on your phone)
This is one of those fields of study that are so mind-bogglingly complex that, short of having a supercomputer close to hand, we can only approximate as to the details. See also weather, markets, and any other complex/chaotic system you can think of.So anyone who can get a handle on what is actually going on with this stuff gives a whole 'nother meaning to the concept of smart.
September 2021
Think You're Smart Don'tcha: Figure This Out And Make A Million Bucks
In last week's post "Fluid Dynamics (and the filth on your phone)"
I made the assertion "This is one of those fields of study that are so
mind-bogglingly complex that....", without supplying any supporting
statements or facts.
(in these situations the reader can assume I am
relying on the Charlie Munger all-purpose turnaround: "Think about it a
little more and you will agree with me because you're smart and I'm
right.")
June 2023
Figure This Out And Make A Million Bucks: Now With Penguins
First up, the penguins, from Chalkdust, (A Magazine For The Mathematically Curious)....
June 2023 Follow-up To "Figure This Out And Make A Million Bucks..." There
is a lot more money involved than just the million dollars from the
Millennium Prize for understanding fluid dynamics and turbulence. In the
climate arena the coupled climate models are still not all that
skillful when trying to comprehend the interactions of the sea and the
atmosphere, a huge and extraordinarily complex part of the whole picture
and not that well understood.
On a much smaller scale,
understanding turbulence can be worth hundreds of millions to billions
of dollars when siting turbines on a wind farm.....