Big Numbers, Small Numbers Are Processed In Different Sides Of The Brain
From Science 2.0:
Left and right brained makes a difference, even for those good at math. 
Large numbers are processed in the left side of the brain while small 
numbers are processed in the right side of the brain, according to a new
 paper.
The brain is divided into two halves - the left side 
controls the right half of the body, and vice versa. Generally, one side
 of the brain is more dominant than the other. For example, people who 
are right-handed tend to have more activity in the left side of their 
brains.
Previous studies have highlighted the general region 
where the brain handles numbers - in an area called the fronto-parietal 
cortex, which runs approximately from the top of the head to just above 
the ear. But scientists are in the dark about how exactly the brain 
unpicks and processes numbers. However, previous observations from 
stroke patients, who often suffer damage to the right side of their 
brains, have given clues that suggest large numbers and small numbers 
are handled on different sides of the brain.
 
  
Right Cold (Right side of the brain activated) Baseline shows the 
participants drawing a clock blindfolded. Caloric-only shows the clocks 
drawn by the participants as they had cold water trickled into their 
right ear. Caloric plus RIV shows the clocks drawn by the participants 
as they had cold water trickled into their right ear and watched 
vertical or horizontal lines through goggles. In the latter two 
conditions the volunteers showed a preference for small numbers. credit:
 Imperial College London 
Dr. Qadeer Arshad, lead author of the 
study from the Department of Medicine at Imperial College London, said, 
"Following early insights from stroke patients we wanted to find out 
exactly how the brain processes numbers. In our new study, in which we 
used healthy volunteers, we found the left side processes large numbers,
 and the right processes small numbers. So for instance if you were 
looking at a clock, the numbers one to six would be processed on the 
right side of the brain, and six to twelve would be processed on the 
left."
In their study, the team temporally deactivated either the
 left or right side of the brain of healthy volunteers. They did this 
using a complex technique – the volunteers were asked to wear goggles 
that showed them a picture of either a horizontal or vertical line. At 
the same time, the participants underwent a procedure called the caloric
 reflex test. This is commonly used to diagnose ear and balance 
disorders and involves trickling either hot or cold water into a 
person’s ears....MORE