Tuesday, February 27, 2024

Goodbye Guys: "The Y Chromosome Is Vanishing. A New Sex Gene May Be The Future of Men"

From ScienceAlert, February 23:

The sex of human and other mammal babies is decided by a male-determining gene on the Y chromosome. But the human Y chromosome is degenerating and may disappear in a few million years, leading to our extinction unless we evolve a new sex gene.

The good news is two branches of rodents have already lost their Y chromosome and have lived to tell the tale.

A recent paper in Proceedings of the National Academy of Science shows how the spiny rat has evolved a new male-determining gene.

How the Y chromosome determines human sex
In humans, as in other mammals, females have two X chromosomes and males have a single X and a puny little chromosome called Y. The names have nothing to do with their shape; the X stood for 'unknown'.

The X contains about 900 genes that do all sorts of jobs unrelated to sex. But the Y contains few genes (about 55) and a lot of non-coding DNA – simple repetitive DNA that doesn't seem to do anything.

But the Y chromosome packs a punch because it contains an all-important gene that kick-starts male development in the embryo....

....MUCH MORE

 The spiny rat story is not as encouraging as the writer seems to think.