From SciTechDaily, November 15:
Researchers from Baylor College of Medicine, Stanford University School of Medicine, and their collaborators have identified a novel compound called BHB-Phe, which is naturally produced by the body. Published in the journal Cell, their findings reveal that BHB-Phe regulates appetite and body weight by interacting with neurons in the brain.
Until now, BHB has been known as a compound produced by the liver to be used as fuel. However, in recent years, scientists have found that BHB increases in the body after fasting or exercise, prompting interest in investigating potential beneficial applications in obesity and diabetes.
BHB-Phe and Its Role in Metabolism
In the current study, the team at Stanford University led by co-corresponding author Dr. Jonathan Z. Long, associate professor of pathology, discovered that BHB also participates in another metabolic pathway. In this case, an enzyme called CNDP2 joins BHB to amino acids. Furthermore, the most abundant BHB-amino acid, BHB-Phe, can influence body weight and metabolism in animal models.
The Baylor team, headed by co-corresponding author Dr. Yong Xu, professor of pediatrics – nutrition and associate director of basic sciences at the USDA/ARS Children’s Nutrition Research Center at Baylor, took on the task of investigating how BHB-Phe influences feeding behavior and body weight in mice....
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